SCIENCE | SUPPLEMENTS
Ca-AKG, or calcium alpha-ketoglutarate, is a compound that combines calcium and alpha-ketoglutarate, an intermediate in the Krebs cycle. It is used as a dietary supplement believed to support cellular energy production, improve metabolic function, and potentially slow aging by influencing mitochondrial function and reducing oxidative stress.
Alpha-ketoglutarate (AKG), a key metabolite in the TCA cycle, has been shown to offer various health benefits. Research in Cell Metabolism (2020) revealed that AKG extended lifespan and reduced inflammation in aging mice (Cell Metab, 2020). Another study in Aging (2019) found that AKG supplementation extended lifespan in Drosophila by inhibiting the mTOR pathway and activating AMPK signaling (Aging, 2019).
In cardiovascular health, AKG improved arterial elasticity and stabilized redox homeostasis in aged mice, as reported in the Journal of Physiology and Pharmacology (2011) (J Physiol Pharmacol, 2011). These findings suggest that AKG may promote longevity, enhance stress resistance, and support cardiovascular health by modulating metabolic pathways and reducing inflammation.
PUBLICATIONS
- Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.
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- Cell Metab. 2020 Sep 1;32(3):447-456.e6.
- Design: Study on C57BL/6 mice evaluating AKG on healthspan and lifespan.
- Summary: AKG promotes a longer, healthier life by reducing systemic inflammation, suggesting its potential in extending healthspan and lifespan.
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- Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK.
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- Aging (Albany NY). 2019 Jun 26;11(12):4183-4197.
- Design: Study on fruit flies examining the effects of AKG on lifespan.
- Summary: AKG extends lifespan in fruit flies by activating AMPK signaling and inhibiting the mTOR pathway, indicating its role in longevity.
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- Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice.
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- J Physiol Pharmacol. 2011 Feb;62(1):37-43.
- Design: Study on aged mice evaluating the effects of AKG on redox state and arterial elasticity.
- Summary: AKG enhances redox homeostasis and arterial elasticity, indicating its benefits in reducing oxidative stress and improving vascular health in aging mice.
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