SCIENCE | SUPPLEMENTS
Glucosamine is a dietary supplement commonly used to promote joint health, particularly in the treatment of osteoarthritis. There is emerging evidence suggesting potential benefits of glucosamine on longevity.
PUBLICATIONS
- Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.
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- Nutr Cancer. 2023;75(3):785-794. doi: 10.1080/01635581.2023.2173258. Epub 2023 Jan 30.
- Design: Liu B(1), Yang W(2), Zhang K(1).
- Summary: The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention. This meta-analysis found that glucosamine and/or chondroitin intake was associated with a lower risk of colorectal cancer and lung cancer.
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- Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis.
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- Arch Orthop Trauma Surg. 2023 Jan;143(1):409-421. doi: 10.1007/s00402-021-04326-9. Epub 2022 Jan 13.
- Design: Meng Z(#)(1), Liu J(#)(2), Zhou N(3).
- Summary: The combination of glucosamine and chondroitin is effective and superior to other treatments in knee osteoarthritis, reducing symptoms and improving function, with no significant safety concerns.
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- Genetically predicted glucosamine and longevity: A Mendelian randomization study.
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- Clin Nutr ESPEN. 2022 Jun;49:556-559. doi: 10.1016/j.clnesp.2022.03.029. Epub 2022 Mar 22.
- Design: Yoon SY(1), Narayan VP(2).
- Summary: Lifelong higher levels of glucosamine may increase life expectancy, with positive effects associated with maternal age at death.
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- Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.
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- Ann Rheum Dis. 2020 Jun;79(6):829-836. doi: 10.1136/annrheumdis-2020-217176. Epub 2020 Apr 6.
- Design: Li ZH(1), Gao X(2), Chung VC(3), et al.
- Summary: Regular glucosamine use is associated with lower mortality due to all causes, cancer, CVD, respiratory, and digestive diseases.
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- Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction.
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- J Appl Glycosci (1999). 2018 Aug 20;65(3):37-43. doi: 10.5458/jag.jag.JAG-2018_002. eCollection 2018.
- Design: Shintani T(1)(2), Kosuge Y(1), Ashida H(3).
- Summary: Glucosamine extends the lifespan of C. elegans by inducing autophagy, suggesting potential anti-aging benefits.
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- Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.
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- Rheumatol Int. 2018 Aug;38(8):1413-1428. doi: 10.1007/s00296-018-4077-2. Epub 2018 Jun 11.
- Design: Simental-Mendía M(1), Sánchez-García A(2), et al.
- Summary: Oral supplementation with glucosamine or chondroitin sulfate reduces pain in knee OA, but there is no additional effect when combined.
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- Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials.
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- J Orthop Surg Res. 2018 Jul 6;13(1):170. doi: 10.1186/s13018-018-0871-5.
- Design: Zhu X(1), Sang L(2), Wu D(2), et al.
- Summary: Oral chondroitin is more effective than placebo in relieving pain and improving physical function in osteoarthritis.
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- D-Glucosamine supplementation extends life span of nematodes and of ageing mice.
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- Nat Commun. 2014 Apr 8;5:3563. doi: 10.1038/ncomms4563.
- Design: Weimer S(1), Priebs J(2), Kuhlow D(3), et al.
- Summary: D-Glucosamine extends lifespan by mimicking a low-carbohydrate diet, enhancing mitochondrial biogenesis, and promoting autophagy.
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- The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature.
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- Osteoarthritis Cartilage. 2011 Apr;19(4):375-80. doi: 10.1016/j.joca.2011.01.007. Epub 2011 Jan 18.
- Design: Dostrovsky NR(1), Towheed TE, Hudson RW, Anastassiades TP.
- Summary: Evidence on glucosamine’s effect on glucose metabolism is mixed, with some studies indicating decreased insulin sensitivity and increased fasting glucose in humans.
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- A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.
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- Diabetes Metab Res Rev. 2011 Jan;27(1):14-27. doi: 10.1002/dmrr.1150. Epub 2010 Dec 7.
- Design: Simon RR(1), Marks V, Leeds AR, Anderson JW.
- Summary: Glucosamine has no significant effect on fasting blood glucose levels, glucose metabolism, or insulin sensitivity in healthy subjects, individuals with diabetes, or those with impaired glucose tolerance.
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