Hyaluronic acid (HA) is a vital component of the extracellular matrix of the skin, playing a significant role in maintaining moisture and elasticity. As we age, the natural levels of HA in the skin decrease, leading to dryness, wrinkles, and sagging. A study explored the potential of an HA matrix ingredient, derived from rooster comb, which was found to have regenerative, anti-aging, and antioxidant properties. This matrix, composed of 67% HA, along with other essential components like dermatan sulphate and chondroitin sulphate, demonstrated significant biological activity in vitro. The study suggests that the HA matrix can be effectively absorbed in the intestine, indicating its potential use in both topical and oral applications for skin care (Int J Mol Sci, 2023).

The benefits of oral HA supplementation have been highlighted in several clinical trials. One randomized, double-blind, placebo-controlled study involving 60 subjects with signs of skin aging evaluated the effects of a food supplement containing full-spectrum hyaluronans (FS-HA) of varying molecular weights. After 28 days of supplementation, participants showed significant improvements in skin hydration, wrinkle depth, and elasticity. The study concluded that oral FS-HA could effectively ameliorate skin aging symptoms, providing a convenient and safe way to enhance skin health from within (Eur J Dermatol, 2021).

Another study further supports the efficacy of oral HA supplementation. Conducted over 12 weeks with 40 healthy adults, this double-blind, placebo-controlled trial found that daily intake of HA significantly improved various skin conditions, including wrinkles, stratum corneum water content, and skin elasticity. The study’s findings suggest that oral HA can effectively reduce wrinkles and improve skin hydration, providing a non-invasive option for those seeking to maintain youthful and healthy skin (Nutrients, 2021).

These studies collectively underscore the potential of HA, both in topical and oral forms, to combat the signs of aging and improve skin health, making it a versatile ingredient in skincare and nutraceutical products.