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Melatonin

Melatonin, produced in the pineal gland and other tissues, serves various roles in the body, including regulating circadian rhythms, reducing inflammation, promoting mitochondrial biogenesis, and managing energy metabolism.

Melatonin

PUBLICATIONS

  1. Effects of melatonin on blood pressure, arterial stiffness and quality of life in postmenopausal women: A randomized controlled trial.
          • Complement Ther Med. 2024 May;81:103026.
          • Design: Double-blind, placebo-controlled study on 41 postmenopausal women aged 55-75 years.
          • Summary: Melatonin supplementation (10 mg/day) was well-tolerated but did not show significant improvements in pulse wave velocity, blood pressure, or quality of sleep compared to placebo.
  2. Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study.
          • Nutrients. 2023 Aug 10;15(16):3523.
          • Design: Crossover, double-blind, placebo-controlled study on 30 patients with T2DM.
          • Summary: Melatonin supplementation increased glycemic variability, suggesting caution in its use for patients with T2DM.
  3. Essential Hypertension and Oxidative Stress: Novel Future Perspectives.
          • Int J Mol Sci. 2022 Nov 21;23(22):14489.
          • Design: Open-label randomized study on 23 patients with essential hypertension.
          • Summary: Melatonin supplementation improved arterial stiffness and reduced oxidative stress markers in patients with hypertension.
  4. High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
          • J Pineal Res. 2022 Aug;73(1):e12801.
          • Design: Randomized crossover study on 24 healthy older adults aged over 55.
          • Summary: High dose (5 mg) melatonin significantly increased sleep efficiency and duration during both biological day and night.
  5. Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
          • Biol Trace Elem Res. 2022 Mar;200(3):1010-1019.
          • Design: Randomized, double-blind, placebo-controlled study on 84 women with PCOS aged 18-40 years.
          • Summary: Co-supplementation of melatonin and magnesium significantly improved inflammatory markers and oxidative stress levels in women with PCOS.
  6. Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial.
          • Trials. 2021 Mar 25;22(1):231.
          • Design: Double-blind, randomized, placebo-controlled trial on 50 T2DM patients.
          • Summary: Melatonin supplementation significantly reduced systolic blood pressure, mean arterial pressure, and several anthropometric indices, indicating improved cardiovascular health in T2DM patients.
  7. Melatonin Supplementation for Six Weeks Had No Effect on Arterial Stiffness and Mitochondrial DNA in Women Aged 55 Years and Older with Insomnia: A Double-Blind Randomized Controlled Study.
          • Int J Environ Res Public Health. 2021 Mar 4;18(5):2561.
          • Design: Double-blind randomized controlled study on 38 women aged 55 years and older.
          • Summary: Melatonin supplementation improved sleep quality but did not significantly affect arterial stiffness or mitochondrial DNA in women with insomnia.
  8. Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.
          • J Pineal Res. 2021 Mar;70(2):e12706.
          • Design: Double-blind, randomized crossover study on 20 healthy young men.
          • Summary: High doses of melatonin reduced insulin sensitivity and increased lipid oxidation, suggesting potential negative impacts on glucose metabolism.
  9. Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.
          • Iran J Kidney Dis. 2021 Jan;1(1):22-30.
          • Design: Randomized, double-blind, placebo-controlled study on 60 patients with diabetic nephropathy.
          • Summary: Melatonin administration improved glycemic control, HDL-cholesterol levels, and antioxidant capacity in patients with diabetic nephropathy.
  10. Efficacy of melatonin for sleep disturbance in middle-aged primary insomnia: a double-blind, randomized clinical trial.
          • Sleep Med. 2020 Dec;76:113-119.
          • Design: Double-blind, randomized clinical trial on 97 middle-aged patients with primary insomnia.
          • Summary: Melatonin supplementation significantly improved total sleep time and early morning wake time but had no significant effect on insomnia severity or daytime somnolence.
  11. Nighttime administration of high-dose, sustained-release melatonin does not decrease nocturnal blood pressure in African-American patients: Results from a preliminary randomized, crossover trial
          • Complement Ther Med. 2019 Apr;43:157-164.
          • Design: Randomized, placebo-controlled, crossover pilot study involving 40 African-American patients with essential hypertension.
          • Summary: The study found no significant differences in mean nighttime or daytime systolic and diastolic blood pressures between melatonin (24 mg sustained-release) and placebo conditions. Nighttime dosing of continuous-release melatonin had no significant effect on nocturnal blood pressure in African Americans with essential hypertension compared to placebo.
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