SCIENCE  |  NUTRITION

Protein is crucial for maintaining muscle mass and overall health as we age, playing a key role in longevity. However, there is controversy surrounding protein intake, as some studies suggest that excessive protein consumption may activate mTOR, a pathway linked to aging and age-related diseases. Striking a balance is essential, as too little protein can hinder muscle function, while too much might accelerate aging processes.

Protein is a critical macronutrient, playing a central role in muscle building, recovery, and overall health. While its importance in sports performance is widely acknowledged, emerging research suggests that protein also plays a vital role in promoting longevity. The key lies in balancing protein intake to support muscle mass and metabolic function across the lifespan, while avoiding excesses that may accelerate aging processes.

Protein in Sports: Maximizing Performance and Recovery

In the world of sports nutrition, protein is essential for muscle protein synthesis (MPS), the process that builds and repairs muscle tissue. For athletes, particularly those engaged in resistance training, protein intake can maximize performance, aid in recovery, and enhance muscle mass. According to the International Society of Sports Nutrition (ISSN), most exercising individuals need around 1.4-2.0 g of protein per kg body weight per day to support muscle maintenance and growth. Higher intakes of 2.3-3.1 g/kg/day may be necessary during periods of fat loss or when aiming to retain lean body mass while in a calorie deficit.

The ISSN also highlights the importance of protein timing—consuming 20-40 g of high-quality protein, ideally containing leucine, every 3-4 hours. For athletes, the ideal time to consume protein is often pre- or post-workout to support muscle recovery and enhance the anabolic response. However, protein can also be taken throughout the day to ensure a constant supply of amino acids for muscle building.

Protein for Longevity: Preserving Muscle and Supporting Health

As we age, muscle mass naturally declines, leading to sarcopenia, frailty, and decreased mobility. This age-related loss of muscle tissue can impair quality of life and increase vulnerability to other health issues. Adequate protein intake is critical to counteract these effects, helping to maintain muscle strength and functional capacity. Research suggests that older adults should aim for 1.0–1.2 g of protein per kg body weight per day to support muscle maintenance and prevent muscle loss.

While protein supports muscle health, there is a growing concern about the impact of excessive protein on longevity pathways. Specifically, too much protein—particularly from animal sources—may activate mTOR (mechanistic target of rapamycin), a signaling pathway linked to cell growth and aging. Overactivation of mTOR can accelerate age-related diseases, such as cancer and cardiovascular disease. Moderate protein intake is recommended to strike a balance between muscle maintenance and minimizing potential negative effects on aging.

Finding the Balance: Protein for Performance and Longevity

The challenge lies in finding the optimal protein intake that supports both athletic performance and healthy aging. For athletes, protein enhances muscle growth and recovery, contributing to peak performance. For older adults, protein intake is crucial for maintaining muscle mass and overall health, preventing frailty and age-related decline. However, the optimal approach varies depending on age, activity level, and health goals. Moderate, high-quality protein intake, particularly from plant-based sources, is likely the best strategy for balancing both muscle health and longevity.

PUBLICATIONS

  1. International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
          • J Int Soc Sports Nutr. 2023 Dec;20(1):2263409. doi: 10.1080/15502783.2023.2263409. Epub 2023 Oct 6.
          • Design: Position Statement on EAA supplementation and its effects on skeletal muscle maintenance and performance
          • Summary: The ISSN presents a position on essential amino acid (EAA) supplementation and its role in muscle protein synthesis (MPS), emphasizing its impact on skeletal muscle and performance. Findings include the benefits of EAA supplementation for anabolic-resistant populations and during caloric deficit.
  2. Dietary intake of total, animal, and plant proteins and risk of all-cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies
          • BMJ. 2020 Jul 22;370:m2412. doi: 10.1136/bmj.m2412.
          • Design: Systematic review and dose-response meta-analysis of prospective cohort studies
          • Summary: The study examined the relationship between intake of total, animal, and plant proteins and the risk of mortality from various causes, including cardiovascular disease and cancer. It provided insights on the risks associated with different protein sources.
  3. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults
        • Br J Sports Med. 2018 Mar;52(6):376-384. doi: 10.1136/bjsports-2017-097608
        • Design: Systematic review, meta-analysis, and meta-regression
        • Summary: The study demonstrated that dietary protein supplementation significantly enhances muscle strength and size during resistance exercise training. The benefits were more pronounced in resistance-trained individuals and were influenced by age. Protein intakes higher than 1.62 g/kg/day did not further enhance muscle gains.
  4. International Society of Sports Nutrition Position Stand: protein and exercise
        • J Int Soc Sports Nutr. 2017 Jun 20;14:20. doi: 10.1186/s12970-017-0177-8
        • Design: Position stand from the International Society of Sports Nutrition
        • Summary: This position stand reviews protein intake for active individuals and recommends 1.4-2.0 g/kg body weight/day for most exercisers. Higher intakes may benefit resistance-trained individuals, especially during calorie restriction, and protein distribution throughout the day is key to optimizing muscle protein synthesis.
  1. Diets with high or low protein content and glycemic index for weight-loss maintenance
        • N Engl J Med. 2010 Nov 25;363(22):2102-13. doi: 10.1056/NEJMoa1007137
        • Design: Randomized controlled trial
        • Summary: This study compared high-protein and low-protein diets for weight-loss maintenance and found that both diets were effective in maintaining weight loss, with high-protein diets showing additional benefits for improving body composition and metabolic health.
  1. The nutrition and therapeutic potential of millets: an updated narrative review.
          • Front Nutr. 2024 Apr 30;11:1346869. 
          • Design: Narrative review evaluating the nutritional and therapeutic potential of millets.
          • Summary: Millets are rich in minerals, vitamins, and phytochemicals with therapeutic properties. They correct lifestyle and metabolic disorders, aid in anemia and calcium deficiency, and contribute to a healthier life through economic resource usage.
  2. Unlocking the Potential: Millets and Their Impact on Diabetes Management.
          • Cureus. 2024 Apr 29;16(4):e59283.
          • Design: Review of the impact of low-carb diets, including millets, on diabetes management.
          • Summary: Millets have a low glycemic index, aiding in diabetes management by slowly releasing glucose into the bloodstream. They contribute to weight loss, reduced medication needs, and have potential benefits in preventing and managing diabetes.
  3. Review on Nutritional Potential of Underutilized Millets as a Miracle Grain.
          • Curr Pharm Biotechnol. 2024;25(9):1082-1098.
          • Design: Review on the nutritional benefits of underutilized millets as a replacement for staple grains.
          • Summary: Millets are high in essential nutrients and have the potential to address malnutrition and replace traditional staple grains. They provide numerous health benefits and contribute to food security.
  4. A Systematic Review and Meta-Analysis of the Potential of Millets for Managing and Reducing the Risk of Developing Diabetes Mellitus.
          • Front Nutr. 2021 Jul 28;8:687428.
          • Design: Systematic review and meta-analysis of the glycemic index and health impacts of millets.
          • Summary: Millets have a lower glycemic index compared to common staples, aiding in diabetes management. They are effective in lowering blood glucose levels and HbA1c, and could be used in designing meals for diabetic and pre-diabetic individuals.
  5. Glycemic index of millet based food mix and its effect on pre diabetic subjects.
          • J Food Sci Technol. 2020 Jul;57(7):2732-2738.
          • Design: Study on the glycemic index of millet-based food mixes and their effects on pre-diabetic subjects.
          • Summary: Millet-based food mixes demonstrated a low glycemic index and reduced fasting blood glucose and HbA1c levels in pre-diabetic subjects, making them a beneficial dietary option for diabetes management.
  6. Nutritional and functional roles of millets-A review.
          • J Food Biochem. 2019 Jul;43(7):e12859. 
          • Design: Review on the nutritional and functional roles of underutilized millets.
          • Summary: Millets are a valuable food resource with high nutritional value, including protein and essential nutrients. They help address malnutrition, have potential prebiotic benefits, and are important for sustainable food security.
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